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The agency highlighted risks including dosing errors, contamination, and the use of unapproved salt forms in compounded versions, some of which resulted in adverse events requiring hospitalizations.[3] This followed previous statements by the FDA concerning unapproved GLP-1 drugs used for weight loss, including concerns with compounded versions of the drug, fraudulent compounded GLP-1 drugs, and versions sold falsely for research purposes or not for human consumption.[4] Import Alert 66-80 now ties enforcement to the Green List by authorizing detention without physical examination of GLP-1 API shipments from non-listed firms

Additionally, unlike Wegovy, Mounjaro, and Nevolat, GLP-1 patches are not regulated and have not been approved by the Medicines and Healthcare products Regulatory Agency (MHRA)

To that point, the FDA has recently identified a few issues in compounded GLP-1s on the market

Mistakes I see repeatedly: On the topical side: applying to damp skin, layering acids immediately, using too little product (a barely-visible film isn't enough), and leaving reconstituted products at room temperature for weeks

The condition affects the normal movements of the stomach muscles, which propel food through the digestive tract